ࡱ>  Root EntryRoot EntryAFileHeader;DocInfo(HwpSummaryInformation.   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~BodyText pEAAPrvImage PrvTextDocOptions AAScripts AAJScriptVersion B DefaultJScript?_LinkDocC  !"#$%&')*+,-./0123456789:<=>@ADEFGHIJKMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstu8] <\><Highlighted STAT3 as a Potential Drug Target for Cancer Therapy & Tumor Microenvironment> <\Դ><Hallmarks of cancer consist of sustaining cellular proliferative signals, attenuating cell death, inappropriate replication with lacking growth suppressors, inducing angiogenesis and promoting invasion and metastasis in tumorigenesis. The tumor microenvironment plays an important role in tumor growth and malignancy. Recently, the impact of the tumor microenvironment and tumor-induced immune suppression on tumor progression, has been subjected to intense investigation, and the STAT3, is a crucial mediator of tumor cell progression and tumor-associated immunosuppression. Aberrant STAT3 activation triggers tumor progression through oncogenic gene expression in numerous human cancers, leading to promote tumor malignancy. On the contrary, STAT3 activation in immune cells cause elevation of immunosuppressive factors. 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