ࡱ>  Root EntryRoot Entry-FileHeader;DocInfo(HwpSummaryInformation.   !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~BodyText NPrvImage 0PrvTextDocOptions X-X-Scripts X--JScriptVersion B DefaultJScript?_LinkDocC  !"#$%&')*+,-./0123456789:<=>@ADEFGHIJKMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz8] <\><Current Trends in Next Generation Antibody-Drug Conjugate Technology: Possibilities and Challenges> <\Դ><Antibody-Drug Conjugates (ADCs) have emerged as one of the fastest growing pharmaceutical class of drugs designed to harness the specificity of antibodies with the potency of small molecule therapeutics. Currently, eight ADCs have been approved for therapeutic use: brentuximab vedotin (Adcetris), trastuzumab emtansine (Kadcyla), inotuzumab ozogamicin (Besponsa), gemtuzumab ozogamicin (Mylotarg), polatuzumab vedotin (Polivy"!), enfortumab vedotin (Padcev"!), trastuzumab deruxtecan (Enhertu), and sacituzumab govitecan-hziy (Trodelvy"!), and the clinical success of these ADCs have sparked clinical development of novel ADCs. Lessons learned during the past decade are now being used in the development of next-generation ADCs. 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