ࡱ> !Root EntryF#@*FileHeaderaDocInfoW<HwpSummaryInformation.O"$%&'()*+,-/10.2345678Root EntryF@*FileHeaderaDocInfoW<HwpSummaryInformation.O  98] <\><New perspective of cartilage regeneration using microRNA> <\Դ>< The regenerative potential in damaged articular cartilage caused by osteoarthritis or cartilage injury is very poor, resulting in chronic inflammation and severe pain. Therefore, orthopedic surgeons and researchers have been attempting to develop various methods to promote regeneration of damaged cartilage. Among the various methods, cell therapy using human bone marrow-derived mesenchymal stromal cells (hBMSCs) has been widely used to recreate hyaline cartilage-like tissues from damaged articular cartilage. We identified miR-449a that can regulate the chondrogenic differentiation of hBMSCs and play important roles in the expression of OA related genes via regulation of lymphoid enhancer-binding factor-1 (LEF-1) and sirtuin 1 (SIRT1), in vitro. Also, we have observed the effects of miR-449a on damaged cartilage. To enhance the delivery efficiency of anti-miR-449a in vivo, we synthesized locked nucleic acid (LNA)-anti-miR-449a.>6GIF89aɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!, H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ JѣH*]ʴӧPJJիXjʵׯ`ÊKYv`ZgoU\mҤ__xK_+^xǐ#KLyaf~ylv em,u^`a|w5 B,aEMx씯eFX6/+p{ӠMK{PsߜfEE ^v$̅,T!ۧDհ^}f0~"2X گ¸2f7= rG,o6i!\M" EٺSWІh\ QPV,EJcӽ[l&>2*PFLy2Gл (KBr6[:4dW*SaLs2];k=tĿw?#9 R$3bҌ,kY2Ovd%wEj!c2IHyAaUMrHuThp!rwюv4bDRYς 2s5:9GhsԢT xUV )7=pzԣ$uڶ3UG^졓9(yګaƖs@VM.]T*(j„)jY0q"K߬ean,)<o#ZE Dy.F2 V@>U=M xKDz6FdLYʾtNmgZ"D2Su^Ekڥ6,Sݴb 'yQ>*k9>jZE(ӊ2bJG׷Ũ$$}[~7m3mlahՄRb)mVo{Ys)v"0tc MӪHpw_W`Cp.S:]u0W\YPTiy=ɑ׸ט3݌4날L󂉓Y-82Z3x$Hgsd$aY&krR;WYW[ L~y[hlRϓt7Fyk7Ϋݟm|U pdI*n6m'P4a:##JJ߿浻<뢝Ӫڗʣ}N25,EYio(kSʹP cդj{3v=?%V <5 z1PԧN[XϺַ{`NhOpH@;;``a`0x`a``a`0x  \ h tajou2010D 2 10| ”| $ 2:36:28OXY0028, 5, 8, 1422 WIN32LEWindows_7@m @xF@걿Ab0i‰Ā[Th5Zz?`BpphHx!pѣWnA=s !MZ |A(D!;1窵24zҧ3 Wn5t;8in98kuv'SJSf=MA/~΁A[[Pg_SڔVC;p: m A8 01 $5M`;\"\`EO8ɒt;5d B̫u<#0aaȥMxh@IC KmB.mJ Z>&B".m’3k L撛1tߵU]ǀdvfqc1+slMTR̮26e}K.,rF\.ptA/h|dg טb*$5<+p&8P;* UƭZkk}*x7X涾aݛZeZR%%S}iiJ:}4 .)nqL%SBl)=RrIhn&bg-s 8h V34bH45i*8;3;#)C<C=ԋAేx"P͟n0{oVhQohVn.Ar IOpv?qz2DW+ˮo){3yk=t-?#(֪C{Dw/8tCx."[S'8{F=`9srDJ {hHUeUs׮cTx)\3 ջO.'nD WRu8UfHyܢ[=z ?\A__>E|U=9ЙOyZ,all00_LWJA :tf4zJN@s>@eh O)PL[QB ~>?孋>Fnyvb~k{Oh.ʉ?V SW4/nďLģ"?.&G"`H͌Fi$܏Dh[mPk+9Z{rcrF,xG铈: )$f~1֥dKa`Ka d,WGoI]{<|~ f^T!k^?@ABCDEFGHIJKLMNPQRSTUVXYZ[\]^_`ebcdfghijklmnoqruvwxyz{|~BodyText xFxFPrvImage PrvTextDocOptions FFSection0} ȭ}o`,x{4*u~Fuvl6%B Ϣ]/\!ں5:&՝<(s-:ͺ,ogk-|['$@ꡧ.T}ա񕂕(mDe`k"|DW,MDRjkͦ.̷\YvL^4135hjT9Aho\Q pV󲓻|V]HQ>wfgw]"IId]v#b D444p (2z𡠇-@ V  z D:wΝ]j÷}sϨE 8(pwpƵyڡzd T$>" *\0{RQztG\qjp=)YIN`WQ8~Ag/IcnXǼyѾ9v#s &>9ڞ>ڙ>(a/1)}9䨋<8A >)>&uc=1U>C.E @I}[d,|U1e t*^y77rL0}lw̛aCPtVɑ#9yʫYAey( O7>"w"*eD@4Dr L![5@ wL4d~hWXlsuTEyT}0%BodyText xFxFPrvImage PrvTextDocOptions FFScripts FFJScriptVersion s DefaultJScriptp_LinkDoct Section0}  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNPQRSTUVXYZ[\]^_`ebcdfghijklmnoqruvwxyz{|~Scripts FFJScriptVersion s DefaultJScriptp_LinkDoct 8] <\><New perspective of cartilage regeneration using microRNA> <\Դ>< The regenerative potential in damaged articular cartilage caused by osteoarthritis or cartilage injury is very poor, resulting in chronic inflammation and severe pain. Therefore, orthopedic surgeons and researchers have been attempting to develop various methods to promote regeneration of damaged cartilage. Among the various methods, cell therapy using human bone marrow-derived mesenchymal stromal cells (hBMSCs) has been widely used to recreate hyaline cartilage-like tissues from damaged articular cartilage. We identified miR-449a that can regulate the chondrogenic differentiation of hBMSCs and play important roles in the expression of OA related genes via regulation of lymphoid enhancer-binding factor-1 (LEF-1) and sirtuin 1 (SIRT1), in vitro. Also, we have observed the effects of miR-449a on damaged cartilage. To enhance the delivery efficiency of anti-miR-449a in vivo, we synthesized locked nucleic acid (LNA)-anti-miR-449a.>6GIF89aɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!, H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ JѣH*]ʴӧPJJիXjʵׯ`ÊKYv`ZgoU\mҤ__xK_+^xǐ#KLyaf~ylv em,u^`a|w5 B,aEMx씯eFX6/+p{ӠMK{PsߜfEE ^v$̅,T!ۧDհ^}f0~"2X گ¸2f7= rG,o6i!\M" EٺSWІh\ QPV,EJcӽ[l&>2*PFLy2Gл (KBr6[:4dW*SaLs2];k=tĿw?#9 R$3bҌ,kY2Ovd%wEj!c2IHyAaUMrHuThp!rwюv4bDRYς 2s5:9GhsԢT xUV )7=pzԣ$uڶ3UG^졓9(yګaƖs@VM.]T*(j„)jY0q"K߬ean,)<o#ZE Dy.F2 V@>U=M xKDz6FdLYʾtNmgZ"D2Su^Ekڥ6,Sݴb 'yQ>*k9>jZE(ӊ2bJG׷Ũ$$}[~7m3mlahՄRb)mVo{Ys)v"0tc MӪHpw_W`Cp.S:]u0W\YPTiy=ɑ׸ט3݌4날L󂉓Y-82Z3x$Hgsd$aY&krR;WYW[ L~y[hlRϓt7Fyk7Ϋݟm|U pdI*n6m'P4a:##JJ߿浻<뢝Ӫڗʣ}N25,EYio(kSʹP cդj{3v=?%V <5 z1PԧN[XϺַ{`NhOpH@;;``a`0x`a``a`0x  \ h tajou2010D 2 10| ”| $ 2:36:28OXY0028, 5, 8, 1422 WIN32LEWindows_7@m @xF@걿Ab0i‰Ā[Th5Zz?`BpphHx!pѣWnA=s !MZ |A(&B".m’3k L撛1tߵU]ǀdvfqc1+slMTR̮26e}K.,rF\.ptA/h|dg טb*$5<+p&8P;* UƭZkk}*x7X涾aݛZeZR%%S}iiJ:}4 .)nqL%SBl)=RrIhn&bg-s 8h D!;1窵24zҧ3 Wn5t;8in98kuv'SJSf=MA/~΁A[[u@DO 6C,H,#GB!k0~ 6*7=M*Z:ҙ#?*?ӿT@Y~X+mj3'm[v|:j)%C$Mϼ5#cd߈hoid enhancer-binding factor-1 (LEF-1) and sirtuin 1 (SIRT1), in vitro. Also, we have observed the effects of miR-449a on damaged cartilage. To enhance the delivery efficiency of anti-miR-449a in vivo, we synthesized locked nucleic acid (LNA)-anti-miR-449a.>V34bH45i*8;3;#)C<C=ԋAేx"P͟n0{oVhQohVn.Ar IOpv?qz2DW+ˮo){3yk=t-?#(֪C{Dw/8tCx."[S'8{F=`9srDJ {hHUeUs׮cTx)\3 ջO.'nD WRu8UfHyܢ[=z ?\A__>E|U=9ЙOyZ,all00_LWJA :tf4zJN@s>@eh O)PL[QB ~>?孋>Fnyvb~k{Oh.ʉ?V SW4/nďLģ"?.&G"`H͌Fi$܏Dh[mPk+9Z{rcrF,xG铈: )$f~1֥dKa`Ka d,WGoI]{<|~ f^T!k^jkͦ.̷\YvL^4135hjT9Aho\Q pV󲓻|V]HQ>wfgw]"IId]v#b D444p (2z𡠇-@ V  z D:wΝ]j÷}sϨE 8(pwpƵyڡzd T$>" *\0{RQztG\qjp=)YIN`WQ8~Ag/IcnXǼyѾ9v#s &>9ڞ>ڙ>(a/1)}9䨋<8A >)>&uc=1U>C.E @I}[d,|U1e t*^y77rL0}lw̛aCPtVɑ#9yʫYAey( O7>"w"*eD@4Dr L![5@ wL4d~hWXlsuTEyT}0%