ࡱ>    24 !"#$%&'()*+,-./0135Root EntryDocInfoPrvTextScripts$w$w  !"#$%&'()*+,-./0123569:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdfghijklmopqstuvwxyVjA=Uݑ@:Lbp! X1ΠIF6\p)ndr]3=cB@b59}oG!*0 uc}2Nd*YEe` pOXTWE%<*XCz\W}/>vο΢ZeDi{M۰miT]5Ջ :xLk쟱AZA1xVc )j[`;,Fy6W0ckqMG6p3 Z Gu,PWuc/$>.S꒲~L݇7CSERd+BeF;d{]' R}'EI!S^Q)N 2ly1̧n _E\7 1f37o2M/}~^ʲމʏg3}xNxmt 2[H&v!ɿ ~89GCmj-kݐI;u);EjOYFjl-ħ͸zHݕAj_},`3AD?e;#OWB.؞3BE<A Biospleen Device for Sepsis Therapy and Diagnosis> <\Դ><Mannose-binding-lectin (MBL) is a lectin that plays an essential role in innate immunity. MBL recognizes carbohydrate patterns found on the surface of pathogenic reagents or microorganisms, including endotoxin, bacterial, fungi, and viruses. To leverageits capability of binding to a wide range of pathogens in blood, we genetically engineered the large (650kDa) native MBL protein by deleting its collagen-helix domain that contains the molecule s natural complement-fixation andblood coagulation promoting activities as well as its ability to bind to receptors on macrophages.(1) The remaining carbohydrate-recognition domain and neck domains of the human MBL were fused to human IgG1 Fc, enabling high expression and secretion as well as efficient, rapid and low-cost purification of the smaller (90 kDa), recombinant protein (1). Using the engineered human FcMBL opsonin molecule, first we have successfully depleted pathogenic materials from >u@DO 6C,H,#GB!k0~ 6*7=M*Z:ҙ#?*?ӿT@Y~X+mj3'm[v|:j)%C$Mϼ5#cd߈DefaultJScript4JScriptVersion7 BodyText $w$wSection08) V=U.>H'X݅Aˑ$ (־]]/HHnH* $$$E $(B !D"RPoω@xl_of[HDMnьؼhP;df?( ?K::XsF=0 daFm}#7o4}A~Nƍ]= =es[̡^|I?C50,Ǜ M 5&zhL-uN&?ZTUymgݨ2#t^k:{uլAχ}Tkk"mw." hMNn4oz|&,˭7+.gaivʾ+¸ulTΥ[~VyТG.R:^lzPFOmGw!)oY{J{3ۘy"]+?V;W?o_k')18z)Luh֙/aQ7]"RwGU[bp9*g,6>˰O9~ Vm~xd cy:6 3eXgK=l6k /f+j؞r` L[=;54Yrj/&8bniȾ }9mXe:p(rm臘ÛSdM=8I >4Wn6´Z-%1=mH&.ݱ&52O4ڗ"/eX?FtvVwω,m:Y{EJ.B~uOs,Z]Y }I;헄!yFs8/g3bmU^Tm,%5[XqOh$XOE3MI_ļW'3a2cj7zیN30.3m}3f̘N;fAܑc͘e͘mq9aƜڌ Y3H|̘E`Kfc`cc-3c 8̘:W,^H-Ry.ZEXR;Ş:v )]4P'l7oƽ :@ L')&::&:.mڴlÚP.h~';HǬbBQc1]{ej~ۘXs2r.U;n?mIgFb@.KfgcH^5ܕ{wooa2&4L&)zY6꞉=3 ]"sAz/}9о-YP)3-LǠ3ט^]q({g{nej7lz=fj}Hi)z^}2N< wI;A_ eG$'4 S0ҡ"ꍤK9 ZC"̡ KjuTR$Ik91pJ{Fo`šPc;3#tFhsxK71ozM)}Ϩg6GCt*wL, mclqysE/ammo[թNO26f܍NtOuOWIpȩrr>.i?$&T7-S8 uxָ:X3;uB'1(iϢ r}P @}Hv9MC"蘔 n4}Jћ.2y3oy2\#}*Y-JȊ %;ߕx呝\T?0F53e%q{id$xł6F k"bZ+aҲCs֚XAstS[Im6lKf)i x݌Tb8!8] <\><A Biospleen Device for Sepsis Therapy and Diagnosis> <\Դ><Mannose-bindiPrvImage>DocOptions $w$w_LinkDoce FileHeader nPNG  IHDRjsRGB>IDATx -GU&8C@QQEAP&%(I4 ,XDXP4B@PQ( 铆'=I?a{NN-nq~׆??n|}7~.K/ .2<яW^yeA4GGB׿~x8u~~iu>Osܠ}}{򔧴2|;//^җevZPiykkRJٟ4ݔ6|:>É'#ooktA?v׾뻾k8w]VjeyCf×|ɗ W ۿ5% s9gP//7 Q`LG~R㟇CKw_ڤ|+OOs`;I|( O| |;V7Y:{7@Mr%?Vm/ӎǴNWٚM|;qxɇ>-AЉ37ySrOO -.]f92_e_" /mb4703D7oD ¹g'~MMmrzիQg??<&7i|]tQjӎ㭭b墿Moھh)osm}6.c(1}}7% =_m༕ btZwD}g]zD2f)9JY#DdB/Eg.}|QQ\6)r>n{۶/c?cȳj8j[[t;/jki 9*7 [اHIm#B3@~- 9Gȫu!:,yxJHdRM^ωjoL)cWu\L{R-clWE<הϹΧۑ9@X+^M)gJ?;fsoo"6&^ h6?eWb R7+3OO;5>fؚ>MQ߻ِIow~g~+eI@zi >`˿˧]xy}}- | %aiY=hzЃB2mfr=EHfX;EIrncdCW6KxzӲ)/v.:`a=OԦoM=&4%psZl-F7ݶKx*reJ&UO'_ DB#?-En¢[Hxآ+"JnGⱛH,=%(Y?DKIh)?%(Y?DKҔmMuOǥY+1i*=ŽLTx )q;o ߳Fɓ~׵t牭yd8 ,&yc6{~l{ezo}kWEa/ngv쁝^\\X,EuGO6А@K.=J_i]u1{s/~q/(}ǵpAsN sLˤA: L'} MeoQ):{]SqmdE5cmc=}Ҥo^+>WIй;'0O}jcѯX}vƳ#,@uhM# XjH{c+B{woW~W?1??}[ݱW~&\ʷ- l Ke? ^XPBKC.~ӟdm/?mQ@|8'vGa/lK!x׬f^561nzιޯXgqhCStE6|iOy`k`}1r=J=Tq&}<N% Qsw]|4D0sykq[`y&s~G Lk $yجu :@ٰ:N&`v RVeZi!-x(~6tۧrPaZ $дuP`l)_-lO\1/|=&HӝvUSO&6!4#O~r^_j(t$)/;o??qVMlx6=X,hNJd :M,Bh;?PīO$i%j.sQz 6{z+k[M 60[VotJVVWT_TOJV`|V_vdlQi{+09nlvݧ4k׭Zm𱷚[{7nk}eF̋Վ6Me60ieyVZ_#῾n{9+=̫9S@.2{̧[=;J^`Fүl=/׭Lva^n?&W76;;bmuN#;:$v40f vJZ-oWMY\L Ί!܃~yL ?L3\ Hx&-llm?i6X{zI`[HXuyJy٭B9s RO#a K@+E}#N}IA᱓7 PJڎzlmML xi?SJ7~Θ]SA!)mKiˏb"A)NӈffM-lv|*OSN }Ԟ&2?$뽚zN;#/>v4E2ŽLTYaN`UX(m[sgRl_(:܎?wY(z&՝J}PPp xZRgI͉㖗^L))oü)eH&BKG+#Ub/{XOuzϞ]{[$d͝%mDprŚӕ8=K?iOk.hĉxhZ/ ZmOLo% x ,okf>3?sX)x`y&bT&q[u"bI%pob?Bh/1J%+L *1QD c쒠!eKos4yqaˤSl{Ϧx^aCOdD~devJ67Kʹ7s~Фdz758շo3YG=)7凴ڌg?Wɲ|J徱šW5Ȥ9(ڻ<׽W¯S/2(o8m_6>+|MҖ6)G=Mԫ&)*g ]L7'8cf od259`66pliغ?#?>ld6W}nifsCMn ;Gip°20Q֮Fxr?X3CÎJ-hq?90SdΨG;3)-1*^)5P ;}h|:ٜ |u ?glD>'g°oڳi8ԏG$>ѳv\8)%ކu#.\Z~޺ۗpO38)ұԶA u4ڤ $G{t{}cOֻ(YOS)]>qqN^t}t=MR>/{ljKj=uX=}+򞦿]goPcSze}Ѻz^&&&-lkpbSSo֟H$1$N v~`oqa[Y`z$f>(~܇ͮ$GD ̞'T01<^{e,8hMDxsJEQ6]:&nu[0*`|zX6o3)hCD'PKԄ&S-oyˠ:cMJ~s))Xctũs&k|]=M-ul{õ>yq ttJgƆ(O=:ߦ:IS@TUkXހЦ~wdkqv6]R?0 B59Yxǀ>aQVX?@M%TýT/:}cj(Ym6X7̉onZ%^(`6 ^- x @B\J PXkyRxtctBvE(8\@B≗ >KHȻa@˗ob-r`Ͼy|Ud/@Xsҍ7VLؔAB]&$5eA[/G޵,4cGѦsoi֯yu_y^SuG4ڪ)6vc8͉8;|bSgmʞdUgϢI{eQمw]N`>m΂ةV4&?3K؜>\XVgN֊ 6%/N &crp PYEG"?>YJ/XAwA=ƥMQr sd]4g6C1_Dik+q&لLY,30ICGqدIxJ'Wvw <6{hٱxqd]&e(#ٓ؞L6,ݷDαQ=\l~C'eϾqazXڣqǁi_Sı,B%Ĕik\ݔB4KdQysuROzˋQ|J ,<GS)9ݣ=|;H~S1fR:B:kOYO+ߧ<)&1|se}yhj{hjyR翫߶]z|(x7Cvt %|/-.S=>vs5`"a`̡}8;/W͖ }CgHaœ3Gs08R( ;e]6\|͔rY$Ȉ͞g' HK\";<Wak0!XU(wq0od5{s/ogօeԀB63E()e1f:wqša)Ga(3oFN &9iK&sWG ?BS_]PDZAx@?ED{Cԩ#=MŮRyC'(ʜ ʰ._ٶi< /yp.CqѶ5>H^a#:^w%K`*%=c[V  ~|Сt9O~:DZǎS-W MX랗Mo#`HvK-gL/63VGwٟl5c'S:%>RvȭxZFV|)c} [GY|=~iݲ#X>aMm 틌&ڊ=~#?6|JgaxZ#;׺w;G[k z~Ok߷Uk?ʧΛMDK٢46jh>@!ǗsϰS6s)|Ո贳LȤO®%)c9*#2=7ٽ0*̑<{%f 8_2@q$ |$ @os̓&NAݚ8U@\$%dRxx`3+XRxĺGK]y@D3;g}9OX[j&=)}M"n;6:0w-i%ղzru^Ju<6LscaPAʫa)wrbEII?s-/RkYބʓaf>9&<)漷"W:7'ߌ3I`'g]girH@E$J5Wjߧs`-60eݴ?Qo>̎2ϖ*N!fagH#N=bkǃBV̛8f5NWؼ9gS>8v̔UB6)e(UuG)69;B-~?۔D7jvKѽpvP&OC6OhNk-CA[&lbGW۩is,LR?Ǵcsl4#y9O֎ŐT˓/!ey>{%>La,WS);1/{[Q| ̅lT_Ce;ƕyM=:ux奬z<jyxףESUOۿ nx^5F&M&ﳲ'BW(8 `(#Mlӹ~6KpؕR*=\Yc?4Cg<74DU0ʶMy q~&}2ޤ(dzý7 fp ُ< ]ㇿg7fdE%c}fqzc*MH )P(5pg>sxئjL׼o >D6PcDc%ˀR.oVI j",[3jq,@ *OTWh7m F 8AxC,I`[K(TQ`C7oYNy@oLE $rŸrWsԩ8=3E:خ ͧn;O|R2Azԣ&Qbs=go`à#qζeTMsL)+um{#Qboo76Z+f%oi$ܻm|*D 5%0_VO*ߪ1}@%I}^]I'Z|]W^\4wUR>Vi_"aU9խi'c]&>̛2!vn[mh Y_0._FL)Drduko v2;׀G<["ɴK}/ƀ-.Z-9B{ՠ&_5N}{&j%CI>G77\ppj NK (FN"Wt0ؾMK.iu7{%f"e:[` H 1h2carxSF|=8UrWZě~hJ#Z})P?ǀ%# (=Q" C⡥|6!i۝RV9)Kt^ fr~=;U9APG>oތym#XԼz^i=W?f}L}QO#^:5E65o1ZkLeN %[ LoG"gϽ' |.sTkX~'.oZ8r1gS?^8tܧ\5ЇOS륬Vͯjm-ۿk>$ؕl7SĮ4⿭<|&y)*C՛~fWK`=[7HL')yN[<<#/xC]N hM8:9|ݬ1^xݒǸr99]Ƕ3>98:d}"LY#w0; A#Å=؞4;:;@_ ych&,]i! \t^kL`rp0E]go8L n<(:|$asF6g\M<{mqfP])%[F:,aKٙ (4`7zfLIti+vg/٩ʴC~?z<hGɶ_EU˃m>LWaUkM穗uxl|+VkHSb /Ss L{Gc|}]ֲԍYS-: (U-,b'¿[ӥ>׳8Mm:m㡦칐QBh2Dv7"W"gZK$[0GۀY":f[HX`>hwºXE @TGRlGv+=yJWb'N3&Wl>ַn 7r"'>Ū#RsRx~ fD;`Q`5"`f(y꿇CUXLx ҪJS-FޙSX*fA9[kjIbPcX˜>Pʇ#x[&>ħﯰ?םe̋u$ PvcK BnCk/LԘ:'^ڴ&'.6ذ>+,+cÊVc [`T1&:N7bijWb, Ytɏ'Q 쀓. 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