ࡱ> Root Entry4,+!'FileHeadereDocInfoVKBodyText `/,+`/,+ "#$%&'()*+,-./01234Root Entry4,+'FileHeadereDocInfoVKBodyText `/,+`/,+ 58] <\><Mother s Obesity, Delivery Mode, and Newborn Gut Microbiome> <\Դ><The gut microbiome is a unique ecosystem that influences metabolism in humans. Experimental evidence indicates that gut microbiota can transfer an obese phenotype from humans to mice. Since mothers transfer pioneer microbes to their offspring during labor, the association of neonatal gut microbiota composition with maternal body mass index (BMI) was evaluated. Compared to neonates delivered vaginally to normal weight mothers, neonates born to overweight or obese mothers had a distinct gut microbiota community structure, enriched in Bacteroides and depleted in Enterococcus, Acinetobacter, Pseudomonas, and Hydrogenophilus. These microbial signatures are predicted to result in functional differences in metabolic signaling and energy regulation. In contrast, among elective C-section deliveries, maternal BMI was not associated with neonatal gut microbiota community structure. These findings indicate that excess maternal pre-pregna>GIF89aɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!, H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ JѣH*]ʴӧPJJիXjʵׯ`ÊKYv`iTݵtʥ-[uẃ+^̸1Ð#KL˘_n "-m9?waԄ' فkĝW7{M1S=t!#gvk͛oY4 ËF^etN'>e}zdUElלC1(!HUhf8Lzwn6os$nW[MQ,g]}V#w;!T!f)yYyiYG#iV"!ۀ@$q:(X\~"xILwɡMіwYB'%gN9{ qݜQvHR7CyOyfĤ~BB*!&X.(wp2~<>jiѩBY1;J"*~X^Wh+YfUNܘ>ynn)'A16Vvfhr:JPbJ鰝ڈcIoZ|yﴩ& yb|[nÏb3fƎrg*IG1up;"59+.|q{mu*^#1贪5ȎkZr0fm8Kgs}oniW&h"^&;j +;J8~>ձY3ι۪]]Ӳ!4Ԭ:ܩ0ɿd{]+ -uNqkG2*sި(F4\#B2MK&HgeBו!kQǧښ+t1o^'I'>L%_JIQ]J=g"ǴCHKI1;xF2 |ꋝ(ץ Iғ4M 9;i ӂ;JПd&2`t$iLGn&ͨFCQn.)D-'ȝKg9)%94)%QZh4I*,}Ӎi.?ʔt,jO5bT>R SjGX-.iRNbU'R—mRbQ&́\%D73ǭ5\UWJUO&ecK½5+ѮGSfq#yYMjͶt\V>Ԙ4j[ܶP]LZ) ud%ȰvElӮJTÚG oZ^SLOn"lV#m/Q;Y^Wӵo70cU,ǐh:Qhœݮa"T ꩃWOY.~c/s`k8<1cK+a!:6Nb%֪Nf*}\\1[JAuu4d-$_^8߫1mLιuo4 oNtBsZb9yos?\}Jnca[R) 䌣qlEوVxFirUN}ƙDrO tNJ.4VDF u1kR/{Q2oyez?knKҙRu nlv۞^=.k1y]j޽+Mޛd}:&N1l:oY[S|Gx,|Mļ,ιW똞@ЇNHOҗ;PԧN[XϺַ{`/z@;`a``a`0x    ajou2010D 2 10| ”| $ 2:36:28 Hakdong Shin-9, 1, 1, 3304 WIN32LEWindows_Unknown_Version@m @9/,+@LŴZWkAfe(kkf)ʱAZцZx?J)F# A=z"fwd[*/fmM!(. mrkg mFvK,jK2Vƀ"^\JI@q 0"Q]aW;ԑӵp u.5&ѡe%KFcW9RN"Dq.t'|u >Y}a5n,vpl10٬֓j5 j؂ݗCUI[xM6YuO|)2u/6*}$k>شv-|moOl޴Jp0JׅnF|8${gw|Xɾyw+'joۦ +SD7MV=c|KĜlNȔ͑L?i-N*IM%d0Rpv ٣żˑi݌SL2i![XqLE6wii kqG|ȁؤg'S[Oy?:guPAD!l)[0mJi ag"3mlsݍiP;*mS&~7dS2͇"˟sX_1Ef@ۜ*_m:- WP풿KPǿI C} n;fPA XZ[tVHZAAREšhvɽdGe NN(ѵZ @\ U bxD}OUӑi71CLQ3~zD-L9)b"r" UsT/@¢LU,!;)_Z#) S=\Iai/׽ m-`HWP Document File$ÑWvI3U nVG¾I?o1=1 J,)$ǒto0뚞:z'5u@DO 6C,H,#GB!k0~ 6*7=M*Z:ҙ#?*?ӿT@Y~X+mj3'm[v|:j)%C$Mϼ5#c signaling and energy regulcd߈In contrast, among electi functional differences in metabolic signaling and energy regulation. In contrast, among elective C-section deliveries, maternal BMI was not associated with neonatal gut microbiota community structure. These findings indicate that excess maternal pre-pregna>W?ldv撆R*mPD&JB"پ>ξRA100TBBB0dCY,S)b֡*}>۟ ||ޟϷ=c ,\!|n&+q_vşeVE3:2*߉uL-,>{0ZOzcpL˨oΏ̛ k{@柮3WGc<g`4OqT$"жq젖!qYqg{&9+][/}ܐop6*&&Cq qM"#k{&k+~~8xk9yȕ1J!5uL`(:Wζ%8%\_-:4ΜC'CġD&xІv@ |wa9HH_b.rh=Bmx-L*tP /g>ޛ(G . = +xsgd;CuYtsE-!SCrlh(CWYQ*D#&>Jj"*ʺ|cI6DI%(kn*YwvjUW2b|΀-_Bi .{_e_/_Q9lzڊz&;-F,]F6cUEM#~Mo[cкfA,:>k1j!Fn#. mDU@uP0ˢffQ£kڶ}6k%5],$ց 3xl:8ϩ\ceO)Ud(?0D462iأt?Tn1 &Pkd}[<5_)TծH{(Qu0eBf`A? $|ǣ==otwvg3r|9g<@˓m71W,alrwdkwۮ:9! 9hέ;s*N<[7ώHCc=0Fq96)%0?~;lax?H_A +$k4KbP/ٖ!5mBqp q'ѱ Rf=8r$)!1!/F$W 7vTIS(Aɀ(@~aٽ]Mt뒻δH&LboX*>&5s<f_*QYt]Zq~OT_sw|`EZ!)갧D4 Osl9FhAx|S7Mun&ڎKUYFȠ[ɧ:նˤpy:o)ʱ)٧0ѽ<'5?0}/Ѹjq@N 4yQGaq,%=FWwHp Kݱٔ搜e!I*иZ34<HwpSummaryInformation.NPrvImage t PrvTextDocOptions 4,+4,+Scripts 4,+4,+JScriptVersion o DefaultJScriptl_LinkDocp Section0y !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMOPQRSTUWXYZ[\]^_`abcdifghjkmnqrstuvwxz{|}~ !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMOPQRSTUWXYZ[\]^_`abcdifghjkmnqrstuvwxz{|}~HwpSummaryInformation.NPrvImage t PrvTextDocOptions 4,+4,+Section0yScripts 4,+4,+JScriptVersion o DefaultJScriptl_LinkDocp 8] <\><Mother s Obesity, Delivery Mode, and Newborn Gut Microbiome> <\Դ><The gut microbiome is a unique ecosystem that influences metabolism in humans. Experimental evidence indicates that gut microbiota can transfer an obese phenotype from humans to mice. Since mothers transfer pioneer microbes to their offspring during labor, the association of neonatal gut microbiota composition with maternal body mass index (BMI) was evaluated. Compared to neonates delivered vaginally to normal weight mothers, neonates born to overweight or obese mothers had a distinct gut microbiota community structure, enriched in Bacteroides and depleted in Enterococcus, Acinetobacter, Pseudomonas, and Hydrogenophilus. These microbial signatures are predicted to result in functional differences in metabolic signaling and energy regulation. In contrast, among elective C-section deliveries, maternal BMI was not associated with neonatal gut microbiota community structure. These findings indicate that excess maternal pre-pregna>GIF89aɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!, H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ JѣH*]ʴӧPJJիXjʵׯ`ÊKYv`iTݵtʥ-[uẃ+^̸1Ð#KL˘_n "-m9?waԄ' فkĝW7{M1S=t!#gvk͛oY4 ËF^etN'>e}zdUElלC1(!HUhf8Lzwn6os$nW[MQ,g]}V#w;!T!f)yYyiYG#iV"!ۀ@$q:(X\~"xILwɡMіwYB'%gN9{ qݜQvHR7CyOyfĤ~BB*!&X.(wp2~<>jiѩBY1;J"*~X^Wh+YfUNܘ>ynn)'A16Vvfhr:JPbJ鰝ڈcIoZ|yﴩ& yb|[nÏb3fƎrg*IG1up;"59+.|q{mu*^#1贪5ȎkZr0fm8Kgs}oniW&h"^&;j +;J8~>ձY3ι۪]]Ӳ!4Ԭ:ܩ0ɿd{]+ -uNqkG2*sި(F4\#B2MK&HgeBו!kQǧښ+t1o^'I'>L%_JIQ]J=g"ǴCHKI1;xF2 |ꋝ(ץ Iғ4M 9;i ӂ;JПd&2`t$iLGn&ͨFCQn.)D-'ȝKg9)%94)%QZh4I*,}Ӎi.?ʔt,jO5bT>R SjGX-.iRNbU'R—mRbQ&́\%D73ǭ5\UWJUO&ecK½5+ѮGSfq#yYMjͶt\V>Ԙ4j[ܶP]LZ) ud%ȰvElӮJTÚG oZ^SLOn"lV#m/Q;Y^Wӵo70cU,ǐh:Qhœݮa"T ꩃWOY.~c/s`k8<1cK+a!:6Nb%֪Nf*}\\1[JAuu4d-$_^8߫1mLιuo4 oNtBsZb9yos?\}Jnca[R) 䌣qlEوVxFirUN}ƙDrO tNJ.4VDF u1kR/{Q2oyez?knKҙRu nlv۞^=.k1y]j޽+Mޛd}:&N1l:oY[S|Gx,|Mļ,ιW똞@ЇNHOҗ;PԧN[XϺַ{`/z@;`a``a`0x    ajou2010D 2 10| ”| $ 2:36:28 Hakdong Shin-9, 1, 1, 3304 WIN32LEWindows_Unknown_Version@m @9/,+@LŴZWkAfe(kkf)ʱAZцZx?J)F# A=z"fwd[*/fmM!(. mrkg mFvK,jK2Vƀ"^\JI@q 0"Q]aW;ԑӵp u.5&ѡe%KFcW9RN"Dq.t'|u >Y}a5n,vpl10٬֓j5 j؂ݗCUI[xM6YuO|)2u/6*}$k>شv-|moOl޴Jp0JׅnF|8${gw|Xɾyw+'joۦ +SD7MV=c|KĜlNȔ͑L?i-N*IM%d0Rpv ٣żˑi݌SL2i![XqLE6wii kqG|ȁؤg'S[Oy?:guPAD!l)[0mJi ag"3mlsݍiP;*mS&~7dS2͇"˟sX_1Ef@ۜ*_m:- WP풿KPǿI C} n;fPA XZ[tVHZAAREšhvɽdGe NN(ѵZ @\ U bxD}OUӑi71CLQ3~zD-L9)b"r" UsT/@¢LU,!;)_Z#) S=\Iai/׽ m-`HWP Document File$ÑWvI3U nVG¾I?o1=1 J,)$ǒto0뚞:z'5u@DO 6C,H,#GB!k0~ 6*7=M*Z:ҙ#?*?ӿT@Y~X+mj3'm[v|:j)%C$Mϼ5#c signaling and energy regulcd߈In contrast, among electi functional differences in metabolic signaling and energy regulation. In contrast, among elective C-section deliveries, maternal BMI was not associated with neonatal gut microbiota community structure. These findings indicate that excess maternal pre-pregna>W?ldv撆R*mPD&JB"پ>ξRA100TBBB0dCY,S)b֡*}>۟ ||ޟϷ=c ,\!|n&+q_vşeVE3:2*߉uL-,>{0ZOzcpL˨oΏ̛ k{@柮3WGc<g`4OqT$"жq젖!qYqg{&9+][/}ܐop6*&&Cq qM"#k{&k+~~8xk9yȕ1J!5uL`(:Wζ%8%\_-:4ΜC'CġD&xІv@ |wa9HH_b.rh=Bmx-L*tP /g>ޛ(G . = +xsgd;CuYtsE-!SCrlh(CWYQ*D#&>Jj"*ʺ|cI6DI%(kn*YwvjUW2b|΀-_Bi .{_e_/_Q9lzڊz&;-F,]F6cUEM#~Mo[cкfA,:>k1j!Fn#. mDU@uP0ˢffQ£kڶ}6k%5],$ց 3xl:8ϩ\ceO)Ud(?0D462iأt?Tn1 &Pkd}[<5_)TծH{(Qu0eBf`A? $|ǣ==otwvg3r|9g<@˓m71W,alrwdkwۮ:9! 9hέ;s*N<[7ώHCc=0Fq96)%0?~;lax?H_A +$k4KbP/ٖ!5mBqp q'ѱ Rf=8r$)!1!/F$W 7vTIS(Aɀ(@~aٽ]Mt뒻δH&LboX*>&5s<f_*QYt]Zq~OT_sw|`EZ!)갧D4 Osl9FhAx|S7Mun&ڎKUYFȠ[ɧ:նˤpy:o)ʱ)٧0ѽ<'5?0}/Ѹjq@N 4yQGaq,%=FWwHp Kݱٔ搜e!I*иZ34<