ࡱ> Root EntryRoot Entryе+FileHeadernDocInfo\lBodyText o HwpSummaryInformation.TPrvImage PrvTextDocOptions ееScripts ееJScriptVersion u DefaultJScriptr_LinkDocv  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSUVWXYZ[]^_`abcdefghijklmopqstwxyz{|}~8] <\><Organization and Function of Higher-Order Chromatin Structure in Epigenetic Gene Regulation> <\Դ><The way in which the genome is packed into a highly-ordered chromatin structure in the nucleus, while keeping its ability to coordinate the expression of hundreds of genes during development and various cellular processes, is one of the long-lasting questions in biology. Recent advances in high-throughput chromatin conformation capture methods enabled the investigation of 3D chromatin structure in which distant DNA fragments can be juxtaposed in space. Using this method, we generate maps of long-range chromatin interactions centered on 18,943 promoters in 27 human cell/tissue types to bridge the gap between a large number of putative cis-regulatory sequences annotated in the human genome and the genes they control. We use this information to infer the target genes of 70,329 candidate regulatory elements and suggest potential regulatory function for 27,325 non-coding sequence variants associated>GIF89aɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!, H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ JѣH*]ʴӧPJJիXjʵׯ`ÊKYv`ZgoU\mҤ__xK_+^xǐ#KLyaf~Λz&8ڠ]p 6:1C7{u߻ta]vo{sy\=oSO}p¿O~lx~3_n]x엳~_l9'Z զn`uF\uC穀k9XIxUa(ӆQ` H&af8c/ѨqYx](YdG]E6#IOG\p.:kݭneW2(rTl@'sc):եjJ˘6?Ŋʤ[iȅjA4OLvxPY P<ȧscןI\e$냧O.0"7ݦDą%<80,mh vϑnvh)Gf:vzcIP[Kjr+9][/O/l:A=ǥͣ"4Ll]VmUi:Cyt,=P3Y8=TXskʛt۫5B63[" Stڵa* 0,JAȉG,i6>;S$ލ1g$MMmФZ7]1lH#Ĭ?O\IdR/C25R J\gUWk%+KdȊ' wZ@/CƑs47Qn\ '7զe W\%x2l a3l2?+DaVeݵ1f[WwDRztXDKWrѳQi&Zrxڦ4cR+FsSȮ!٤Cw7"Mpo\h' JYZ[Y̋.dn<.ʳT̻u}O)f4p2{(7sQ~Rn.:^Ojqx(%ڊ7NoV%WeN]6ʱM}kUm/\7 r/ G|PW@'dC磼->p \07mp͡z?IU"`~p{7ωBbM):ߋ`}=xcI.x˷]3OzlBAyC_͵G{Mpױ콝4fg{[ԯ}=f I@B8DXFxHJL؄NPR8TXR;`a``a`0x  X d p|ajou2010D 2 10| ”| $ 2:36:28ajou8, 5, 8, 1555 WIN32LEWindows_7@m @@V=kA~fݍ]̅1$ĨZDЀFR!@0BHB+ }g?dvv{󺣹(JUvHJ2eW}3l*z9Vпk#&{X!gxbonzhW CCBӪ>)߬gLgeVj ĕ|cVNp\jvbY|~./~__>E~7:su՞% *~47;[\]c[zխJͪTuy~:jyog{THWP Document Fileu@DO 6C,H,#GB!k0~ 6*7=M*Z:ҙ#?*?ӿT@Y~X+mj3'm[v|:j)%C$Mϼ5#cd߈latory sequences annotated in the human genome and the genes they control. We use this information to infer the target genes of 70,329 candidate regulatory elements and suggest potential regulatory function for 27,325 non-coding sequence variants associated>W=lU]%lX@4\B0`G4Ʊ  弻;9GuM$RBP@"4( e *J" y7[wJxyS8WQ&/|w+~ãR^%_k=Q]t23%'͵e_{hS=6*Cw=X|zCb^xr˘xԂqYvec^WxNɉd=0d5o՛jki(zU}wJM>]=>bա%'絳WS(ʴ룶.^糧$ۧ>ǣMSF T<ʾKwH:1bO622E ڍt2KhdHR8k[EZ{y{j{km|:h\v⪇Ndo2Gl 6rh29#@y;޷qD=f* l}V.zΜ!G#>M*ff>r؃eAĬ5^pCv`z18MˎaAuMKa}{hG%]}\DY 9cu:&6ERpR+4(ggW倫,ڜlGgNΙd9c0/>29?*k(/% J,d.3F^({XaDy 3Խe1Yd<;7j="o6dm>啤ɫn32-Xl-D  ٭dm z4+^X.;7=z3WxVPX&pfN82kS=dt O;jT ) .:Ekdվr 3wz9SΎ}Z66 ,M7[UKaeEӒ.R%)dVHK%x)0"}6Hw{Q|7ݹ};k peAU%iBQ>9aR'oi>DlD?3A> aA>&OiHǜ']jY n1+N1[KL1/N1H/U;G|sO?O=cbzc.KRfӊpjvaR45Se%4Q/7^7 QWit{ebt_t,t6} )ڣ#1JJ,Zqv:)(CIs\OCDNJ1`O4Vwe7wKk?>n戝Y4 1g2VޯF.k8~#2bL&b~xs%:]PW-QXXFYݽ eUbtwg\E(?7Bkv'nx+7M>d>7I|^ j],.E acdI1)Yib#Gn&I$'zβ]&l` ~_Ynu+J{'5{M3Pk Q[$CiWϭ'-'{-|#6` t`!pmdYl֟v|hfm>`NźFdVǹmޱVcm)F;UͱJ'ZunUAc\9/=jHu{-{ֱFicK. HW_ ktDƴ_[5߽N Tj@}H}ˡCEO5RJNQhC|i)^*!q=|SGOUԱ ]ٝ73o `V8~yYnf^usߏnk\cY5]J\٭Kncpt3pPF57Rditk \>[MRq|z83z=lg]baQ h5-X-ER/{]3rmӺȿr_fO&WU>'uBm1IMN41RQf5dCmZ٣OgjZZ0JhUzᒚ]ju}LXw.F8>Oy .|eC}^oH9'ԧr)QS6Z$sDkMR#K璻VUݟ8~K]LNrNN*:ʩ2d& qZ/6ѷnVG^YaR*X9*WcM]+sG7l }GqjLo(s4+. &