ࡱ> Root EntryRoot Entry04mIFileHeadermDocInfoaBodyText 7mIЅmI  !"#HwpSummaryInformation.YPrvImage =PrvTextDocOptions 04mI04mIScripts 04mI04mIJScriptVersion t DefaultJScriptq_LinkDocu  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXZ[\]^_`bcdefghijklnoprsvwxyz{|}ANCA-associated vasculitis Yonsei University College of Medicine Sang-Won Lee Antineutrophil cytoplasmic antibodies (ANCAs) are autoantibodies recognising typical antigens in the cytoplasm of neutrophils, myeloperoxidase (MPO) and proteinase 3 (PR3). In healthy individuals, ANCAs can be detected with beneficial homeostatic functions, and it is called  Natural ANCA or  Non-pathogenic ANCA . Natural ANCA has lower titres, lower avidity, less subclass diversity and less capability to activate neutrophil than pathogenic ANCA. However, when this regulation is broken, ANCAs initiate pathogenic autoimmunity. Endogenous and exogenous stimuli can convert natural ANCAs to pathogenic ANCAs. Several predictors of subsequent development of ANCA-associated vasculitis (AAV) have been reported: PR3-ANCA was detected at least once in 63% patients with GPA and an increase in PR3-ANCA titre was observed in 62% patients with GPA before diagnosis. Particularly, an increase in CRP level was accompanied with rising PR3-ANCGIF89aɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!, H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ JѣH*]ʴӧPJJիXjʵׯ`X Tkplٰ)Ͼ}{mݻxʅ[ro],w0È+^̸Mm!];-a+e!޲%Wҝ^miС z$絷kͻ5O%dva.Qfʃ3?)}سkνovyeИ\d3,tv?^qEg~d~9j_r EAZyEաy]BeZ|ƟdK'&X*~2"X$F~!G7#4}i9bw%T`saHș{%"`Cjg[Z$#c<. ~G28ٹbxN-YrnIU!Y"}o(#i!R"F)jzyfNOz($<e  Szhj|I萱Qv!ZyI\-Y&g둋F$t|*lfZkɩD-ak~Ijf9qif &KI:cيQܨK:'}K`lz )m0]g+jk2P$; J7 =-s KsSS;+puUjynkJpE-)tVmu̚vIin >쮰XfN 4:܆w'LyJ좢~È&)25,!G0eb]rwʎ)1Q6^$غYp|#/4܋c0%ީOU%ſ ]aZ\P8qANbF-E!Tͬ+cg9AE5I|c!8C@vӉ+ ̀nqG3nwkw }B"LMRӄS'U'$%=u0mvg0k%t'СxbWQ)9CeAl˒^1 k"JY3aCI:aI(5GA}zgHUSaW=ZR8W/)"Uf})Jx"AZѦ񘒪^ @Φ z}"qh2+XeO̘^J H9Fe5o:B1Le:ǹWVw1|ȆJĺ[kU%dI e^ERTb.Դ)«DQgrƈ&?, ,u|V pY *j ܺ59uBj,SZb˱GbܶK%5OhCXWt&x?$[ l5 &a פ^Xƨo{nTdFY&?ĺ+%\jW)kSԪW,8!nTgR5ậ4ڧ9r=2YCۿy!D5:AtMbL.?QÅj`:1O5~S)u?nn٭5:O:*4ۢyX^^$j^Ҟrܸv뮵.^::5>u W G&P/8J`JVe?sg{l䒀VyNkC?VD'׀jto'&]vhdw5f2S(tՁoj<V}kf6h R8FYut'T>Fo.SV1i55G\m>ŗ)^iveGJ2\Bl!Ct,lPiA\V5'~W~7~Fi~SAy9>26`oXxrj,ava*7'?#V{-rxاB#|%q fs瀒6ca`h:0W}-ds#V6q>܁ճ…p8ȇ[(*@B9DYFy6;`a``a`0x  d p | t(YP)2018D 9 11| T֔| $ 3:40:39ajou8, 5, 8, 1555 WIN32LEWindows_7@}}@ЅmI@VMhAfv6Z=ԅ-iR26>ea 3l 쀊>Ռl{Hݑv!*2iL2jh6]8 2E/ISection0B6Pɰp eɏ.Rpʤ,DiUxIM!j#4P*|"*-bQ9L_]2K  OXXz+tgrQl=AY/lpYrݤ%ݰ@Z)kcȚ'Ѫ%ö";[|T41tHՃ0Wܱ4Qng?> 4*}-"lFI쵅싮*odǥ3ۯ"H6 '~ch?e?. HWP Document Fileu@DO 6C,H,#GB!k0~ 6*7=M*Z:ҙ#?*?ӿT@Y~X+mj3'm[v|:j)%C$Mϼ5#cd߈litis (AAV) have been reported: PR3-ANCA was detected at least once in 63% patients with GPA and an increase in PR3-ANCA titre was observed in 62% patients with GPA before diagnosis. Particularly, an increase in CRP level was accompanied with rising PR3-ANC-bWrUmcJ^pb6Pb @Yvۀ(vI#k i$4#%OȆ|/ؑ%Ow,kdFӧOyE|5V+|v&ianxަgߛPcR%ԣN0ޥ y䫠[8:~$ztUgO~ÒcA+!\K/Zaݯjv|Zo׸^D 1ZHv8E2q^=gnJSfxt /cb~!r!39ז/n{xΙ&1};꼽xzoz4[Z-z3F/nX9+nqMh#CˌB#09a=幘>R]"C ,kvɚ.#d{ ݒ;3ddBNb+hgF''O1+?EDԦo,>ϰM]l_PT-~fS,1lK㜢B#蘭T>{a'JۨD&6c 6ևN Vfzphߏ婭Ptc˕;:{=)o (\b\j}:k uMQ\aD/QtN%;)I,Cطx2 4 ˌ{yZX.64x=t+ٕ;tV-U &>ESe5ԷUfkDT}-N Ɲof׬ x=SVMwHgv:KnS9*2xf#"Yr7BY VUuoTx͑᎝^.=~|wsqΫۚÛx68Y죇S؆{~\.U49ϖf<t꫸x󵻐wCEnJ}%[.sR}Sٷ7QqBfߝAZ5ku3^Y7U :HO.8-x :^֝Or[[WsD5B3[++?WU?5AAQ^dI_*/1ш<4p3;;dgwٍ,xؤE,;;;ܙݽ/̙=|;w*(™PF)4)mCz@c#P9uZ5ƛ)Ÿ@r'OcIw!ٍߥ=kw)(5O'moTGڑumkanbTI%N$:s7#C io H*W =d2-_b<49'Q}10utD[Y8.>+ԕ3?ʴʷ陥"ȳ:ډh^ұL}ʹضi?tаD;דtφ1߲C'Ø6\a/<~?0f 3˜~ ; cbodw01ȟL!07: cN}a]0)dX L)D#vwޅΫ1s+-_ 9[t5t Ѳ28  z gHߤmʲy!#c~^cT=@XRwۺx3tXP=C߬eS&Zm%hXG@+Böɦ4Z,>8ȱqr<+oh\# ǮZAvހ7vtlaּsvEXƶج6*9t4mCC܇2͊R59Č ڋAMqAOR -mBru*4z)t08Gh7q#S-٘4!>+mqmefkd/ 15ZzlVĊ|_4?FfZ=۷8vI]%^]̣]}E50ߞ>!2δJdZzVXV! pn,#r8mF+d EL5P X7vP3 KfGv!S<uBDrP̭9zr0G=|9p\ijt \ِ>_W<1'|WZ s |pڏ1=egggG3fcѽߧiV^w߽20Deu-VR[)@; ylL\kA3 {؋}-߉J6i4z\*ʴzhpRT)@/%6-dDz$Pbʑ3Ft]VߔHʕ3AZdƠK`]ڷK]-w>컆qViKo Dh68. Gww:<ӾrT)vT~&kbj]lvZ+[VGswqiGiWێD͏D OXneXxlxiweIflwWԩvz宓r.F~&Ye\F"5ryc~›fG1 -r-XЋY(;"F}XF Tg;aknzէZyQLO\ e,d`ƺcJ2†zX1t \XrdRGGo-g"ͭeMq9)2qiE[9qX)G554)Z5sv"ah=67$3T+kGhɑ6u¨ :ĭ@*Gnzb$׬f@F--'#X{E__i? =7UA"N{Eqڳ2W 4!Gwj5[Y )ϸ#'dsX]R,CQ>tnȏZ *0S"il{0@,na twKHU.ҏ:^<0V;vea@YZ M8V=DI޳K~[jJyúw/5rݰsi@!Vu/P)Ǖn^T޴kUOIx`t"xL7*r2ݬ#v$|҆19C&t<홝3tW97;[U8kNp;f҆vZX]t jVLlfvW3]^t y}n78q"ulkE<M+QC0 0w|;Iv:I1רP{$Bt ''**rKiDRvkM:?ʟ#9F5߱D(_!ZH^=BgR3^EO8siѣ;'^ #=ubQ ^" vXNb ;mu"cprSZ-[G)57;hQ͎yVi1"J Ty@M iه̬fFj! B l,`c-@ - %33 " ̹κi G/yGk1{(Q `T:<\m}!׈2=!"\}zl&S,WYq]$lM]<;gFt+gxU>H>f@.9ztTvVV\͊Tnj)"Z:cLM{C: 诳R&htQuXSD82èDLF!% 9TSN'2ּL:},?qOg|cmt /ts:sXx3M2;ެ-9 S2#t'uf ض3d~ԙ_d֙:L Z{s7?G͆^mm˙:0οs1̟WUG