ࡱ> Root Entry0"(FileHeaderSDocInfoZBodyText л1!#$%&'()*+-.,/012345Root Entry0(FileHeaderSDocInfoZBodyText л1  8] <\><Recent advances and improving strategies of adoptive T cell therapy > <\Դ><Various immunotherapeutic approaches have been developed to activate both innate and adaptive immune responses to recognize and eliminate tumors. Adoptive immunotherapy with antigen-specific cytotoxic T lymphocytes (CTLs) has been also developed as a valid approach to the prevention or treatment of viral diseases and cancers. In our clinical trial of the adoptive transfer of virus or tumor antigen-specific CTLs in patients , the transferred T cells could reconstitute specific cellular immunity. It have been demonstrated that autologous lymphocytes genetically modified to express anti-tumor T cell receptors or chimeric antigen receptor (CAR) can mediate tumor regression. Advances in the understanding of T cell biology and the tumor microenvironment and application of gene therapy have provided multiple novel adoptive transfer strategies for translation into clinical trials. > <\Ԑ><@ ܭ > <Y% (Yլt)><ij><><1977-1>dGIF89aɻxxxkkk]]]PPPCCC555((( d`LH00`Hذ̘`H0|pdXL@`0H `H0`dHL`H0xp`XH@0d LȰ``HH00dLؘȀ`H0xp`XH@d0L `H0d`LH`H0|pdXL@0`$H`dHL00`HذȘdL0xp`XH@0` HdH0ȳ``HHdL0xp`XH@`0H Ը̰ĠऀؘpȈXxHp@h@d8`8X0xT0pH dxddxd`d`p`|``x`p``x`!, H*\ȰÇ#JHŋ3jȱǏ CIɓ(S\ɲ˗0cʜI͛8sɳϟ@ JѣH*]ʴӧPJJիXjʵׯ`ÊKYv`ZgoU\mҤ__xK_+^xǐ#KLyaf~8fle`ϛ;3軰Ceompa߲}ݝ76kݖ>:lxk.6k=eqvG9`M/8.IbO_^vHxZBM{&muAȜpbpRWn!`u(^uv ""ۍ6fr#onB\1(#Z4BTOv$B)x$#fifY~(aou8dofFaD)]y%GS(v&ibidZlh d{H9f]Fbh$i`]x RhDn&\xe;ݎT稞:髭&]*yZVJ(+Jᶖe({GjN[jH^곆酅hcqfy"KmkmƈjZ*\lj{fRiz'K֜i'_6֌ 2捻Cg0k4<[l2+:kԿ:*5\ :Sl6DFNʴݼLv\'lC4jI;z%ti&[\) <0Zn8t0~ݬu[ʠix[q{$)[lr, [:Ï^8x$[1{цHN-b k ߞ낭sȧ7Φ>3>6[vnȹj޾pUDxƳ_b@ [N>єMK㒛 udo< `ԱWAMàX84}huʕIw6Z!?HLB z= /4" yZtTadpǾ-m?rF-pw~H<BG;qh"XD(N>Ly$G6LndUՀN| %Md4+[ N,e옒6qF)!yɡ(s6͝9vaU]r7)I꬝hSڢ}%mQ~]VR` C!Km\.yk\J<5`6Emv]Ե~M ؽT{ؔWO[֚0V >*/1<& es]BJoz2^ƩLnV]NzXٿ՝k-)*|b91L $ūNkOrH_.KqcmP,8O8 5#\'Zൕ&r8e xq uf:~_UϩqyhA˧,90l1StlIHx/'&mW{T}v6Wqm>ڥfuZ=͟Ej8B;oZفՖP˕lkILM#vڳ&neܜ[i;k{oʻ5P <ݘ(OW0gN8Ϲw@ЇNHOҗ.;o"& q{5^ .)b|!Ϫ,`a``a`0x  X d p|ajou2010D 2 10| ”| $ 2:36:28KimTGHWP Document File8, 5, 8, 1485 WIN32LEWindows_7@m @1@VkAN4TcZ(zЃB"jE"m)?PB(z!zѣOll6 }̼oޛff - cOp~0*ۆp\*ܲV]VhZ]%"3m `5_W|bk^8>\B`w @H="pzwy P Y"76H,04@6 ̊k/>m|x~\ 2MݠIN))PczQs.7;bEvS܁I^爮v7*k,22X81$V'qR*]=,ʰ*C qْѫmc}td5b׋nVpԾjj"k74]-Vi3‰MKE9L&: jN'׺%g:\.%_8ܒC]7谠ʺg!)-pq #,ҾNj t i{r~)|{-XLy2Y1ݲH|3;M)sG[}TkQe;M]^QkILR(׈bC੆-x qvmbwJ< y|7;oay+bʀס2sCedXh'J(lT8ʘBo8oojƿ7R9]_)7TnAe L H&c6 l֌% fdp 䳫IPQV80nrD.w˔wqXdY.mՃ8xʼn8ּ'd.WDSf3~:;qI]5BݘhZi\G wn傦gv{$a2D/LG翆NEp|,G|nJ Pj4'Ҫ`U-YbFtz70ۏǣhqJ3vcMf*ӏ_BǛueE!vo]GqXoNjʑ*W"9%V"WpI xMK Ɇ_,|:3K#cu@DO 6C,H,#GB!k0~ 6*7=M*Z:ҙ#?*?ӿT@Y~X+mj3'm[v|:j)%C$Mϼ5#}Wm?x?K:X ~nSV@/D ZN%9cd߈kw~F;ukkUV8Ka5! {V.M8{LBsion. Advances in the understanding of T cell biology and the tumor microenvironment and application of gene therapy have provided multiple novel adoptive transfer strategies for translation into clinical trials. > <\Ԑ><@ ܭ > <Y% (Yլt)><ij><><1977-1>WOhe3;L JT*&Ҫx0ҤibT2$ lj<-H=zPă (b-9\<bAz̡TߟofN ̛~|;c,@ΐ_>ڭT)xkR#ЏǼހ8#/<saiwǕYc r v, ;[JԖP{b EgXqԙ!{&)>}O5P{C$& }q.s|MȠE&!qUϯ3ϲXlwgl39&6SV f},>ݢֹ9ϻ:::h#8BξԹ;\%;qڳuʳɬlQz'פNhS־;??8/ɸoʾَ̈#O܂s<zhZ7y; ĖOHqqUw?k,]u-$$4RRJ0ҠCyءKd +"XCC{ޛIJԻ<2Y& TO>ca8\ p13S0l#7l<t@ip8|qWMDsfT*+SQwd׀@F ͬ`n0s0HMT(YY$ASq0&9 "1Fc.bY&kY,2+3(~QShGjIP$%G9Xi$iI袿`Mhnr`NNԅojbi&a߿=ѡ*gIhƴނF1x~ awО5x==Avp}p;s }pϜոޏ_篭(> vN++*gDΘ{ß a~CBCYtVng)FSחJc5]T~McW[|j`Ҷ1ßx h{޺sRyoB-$ `N wcV?;J.&RyasaÖcX_8Pr|^F bA bW&X/ /gf`(`f {yR  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMOPQRWTUVXY[\]^_`abcdefghijklmopstuvwxyz|}~HwpSummaryInformation.NPrvImage W PrvTextDocOptions 00Section0{ HwpSummaryInformation.NPrvImage W PrvTextDocOptions 00Scripts 00JScriptVersion q DefaultJScriptn_LinkDocr Section0{  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMOPQRWTUVXY[\]^_`abcdefghijklmopstuvwxyz|}~