ࡱ> Root EntryA#(FileHeadereDocInfoTBodyText AA!" $%&'()*+,-./01234567Root EntrycA(FileHeadereDocInfoTBodyText -_A-_A HwpSummaryInformation.LPrvImage PrvTextDocOptions cAcAScripts cAcAJScriptVersion l DefaultJScripti_LinkDocm  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKMNOPQRSUVWXYZ[\]^_`abcdfghjknopqrstuwxyz{|}~8] <\><Microphysiological system based multicellular tumoroid and organoid culture> <\Դ><Microfluidic devices as a translational research tool provide an alternative to animal experiments due to their ability to mimic physiological parameters. There are several approaches available that can be used to predict the efficacy or toxicity of anticancer drugs on cancer cells. In general, standard cell culture systems have the advantages of being relatively low-cost, high-throughput capability, and convenient. However, these models are insufficient to accurately recapitulate complex organ-level physiological and pharmacological responses. Here we present a one-stop microfluidic device enabling both 3D multicellular tumor spheroids (MCTs) and organoid cultures, and drug sensitivity test directly on a chip. Our platform reproducibly yields 3D MCTs and organoids in a size-controllable manner. MCTs and organoids derived from cell line, rat liver and patient tumors can be rapidly proliferate. 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Our platform reproducibly yields 3D MCTs and organoids in a size-controllable manner. MCTs and organoids derived from cell line, rat liver and patient tumors can be rapidly proliferate. 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Ow!="zGbդ1)D%?nDFmiF"Zbώ_q^uz;,_jt5E::0θn}jNlK>h>S~48ղ Y9Y;Nx.hpu64 BDod5$I^Aȥ}M]&[^I}6AlnhlG4G{:0C^r0Ք]lh?q> ;ec h_g[ *j)u2TYOxO] g5eaN 'bÌh=ن#zƤe9v mU&WzFYd3VMhucoDV#_h=-/DǾmckԇ.1{ "^Z^#fKctt5EǶZ$&"s++9gز Hi#[}%ILi9Z Xut8!lK4{PU̪;7DJ(lPQIhTjΨՇ=/VєZO7l.Rhx䁰V*3t?Ȱu aK+ܶZa0t7E;rwvV/po>8;|'[q fO`5eM~̚h̉_kG+,$ !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKMNOPQRSUVWXYZ[\]^_`abcdfghjknopqrstuwxyz{|}~HwpSummaryInformation.LPrvImage PrvTextDocOptions AASection0v1 Scripts AAJScriptVersion l DefaultJScripti_LinkDocm 8] <\><Microphysiological system based multicellular tumoroid and organoid culture> <\Դ><Microfluidic devices as a translational research tool provide an alternative to animal experiments due to their ability to mimic physiological parameters. There are several approaches available that can be used to predict the efficacy or toxicity of anticancer drugs on cancer cells. In general, standard cell culture systems have the advantages of being relatively low-cost, high-throughput capability, and convenient. However, these models are insufficient to accurately recapitulate complex organ-level physiological and pharmacological responses. Here we present a one-stop microfluidic device enabling both 3D multicellular tumor spheroids (MCTs) and organoid cultures, and drug sensitivity test directly on a chip. Our platform reproducibly yields 3D MCTs and organoids in a size-controllable manner. MCTs and organoids derived from cell line, rat liver and patient tumors can be rapidly proliferate. 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Our platform reproducibly yields 3D MCTs and organoids in a size-controllable manner. MCTs and organoids derived from cell line, rat liver and patient tumors can be rapidly proliferate. 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