ࡱ> Root EntryRoot Entry7"FileHeader:DocInfo(qHwpSummaryInformation. ^ _  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]`abcdefghBodyText 7")7"PrvImage PrvTextDocOptions n7"n7"Scripts n7"7"JScriptVersion A DefaultJScript>_LinkDocB  !"#$%&')*+,-./0123456789;<=?@CDEFGHIJLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmno8] <\><Mechanistic understanding of protein secretion in cancer progression> <\Դ><Intracellular transport is fundamental for the proper functions of the cell, as proteins and membranes must be localized properly to perform their function. The Golgi complex has a central role in secretory pathway. Following synthesis in the endoplasmic reticulum (ER), cargo molecules are transported to the Golgi, so that they can be converted to their proper glycosylation form and transported to their final destinations. From the structural perspective, the Golgi is a unique organelle consisting of a series of membrane stacks, as known as cisternae. As such, a longstanding challenge has been to understand how transport of cargoes through the Golgi is accomplished. Cisternal maturation has been throught to explain anterograde transport at the Golgi, but more recently, transport through tubules that connect the stacks has also been suggested. 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